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法国博士招聘-图尔大学-肌萎缩性侧索硬化症(ALS)

如有招聘信息发布(博士/博后/访学)可联系

邮箱:cxw@med.tj.cn

微信:shelver888

公众号链接:https://mp.weixin.qq.com/s?__biz=MzU5NTk2OTE2Mw==&mid=2247485674&idx=1&sn=2450de5325e1c21af17e4aa0867e128a&chksm=fe689d0ec91f1418f388f9631b0a6cc669952b35db97ad2cf82a745db8af09dc52ebc2ff92b9&token=34312708&lang=zh_CN#rd


学校:图尔大学 Université de Tours

院系:Team 2 - Neurogenomics and Neuronal Physiopathology

教授:Débora Lanznaster

申请邮箱: debora.lanznaster@univ-tours.fr & helene.blasco@univ-tours.fr

截止日期:Sept. 15, 2020



介绍


我们正在为三年制的博士学位寻找一个积极进取,有组织能力且独立的候选人。拟开发的研究项目涉及在肌萎缩性侧索硬化症(ALS)的细胞和动物模型中进行药物筛选,并将于2020年10月开始。

ALS是最常见的运动神经元疾病,患者通常在症状发作3-5年后就染上。目前,全球范围内仅一种针对ALS的治疗方法,但效果不明显。在该项目的第一阶段,我们开发了在ALS细胞模型中具有治疗作用的生物医学。在该项目的下一个阶段,该博士生将提高所选生物药物的生物利用度,并测试它们对不同体外模型(包括iPSC)和转基因小鼠的影响,以更好地表征我们生物药物的治疗潜力。

团队:UMR1253 iBrain, Team 2,是由研究人员和临床医生组成的十分多变的多学科小组。我们紧邻图尔医院,使我们能够开发ALS,自闭症和胶质母细胞瘤领域的转化项目。


要求


候选人应具有神经生物学,神经科学或药理学的硕士学位或同等学历(重点是药物筛选)。

期望候选人参与过统计培训,驯养动物和福利事业,但非强制性。

具有细胞培养,分子和细胞生物学方面的知识者优先。

要求英语水平(书面和口语)。


申请


将您的简历,动机证明和两封推荐信(一封来自您的硕士导师)作为pdf文件发送至debora.lanznaster@univ-tours.fr和helene.blasco@univ-tours .fr。



Job description


We are seeking a motivated, organized and independent candidate for 3 years-PhD position. The project to be developed involves drug screening in cellular and animal models of Amyotrophic Lateral Sclerosis (ALS) and will start in October 2020. 

ALS is the most common motor neuron disease and patients usually dye after 3-5 years of symptoms’ onset. Currently, only one treatment is available worldwide for ALS, but with very modest effects. In the first phase of this project, we developed biomedicines with therapeutic effects in a cellular model of ALS. During the next phase of this project, the PhD student will enhance the bioavailability of the chosen biomedicines and test their effect on different in vitro models (including iPSC) and in transgenic mice to better characterize the therapeutic potential of our biomedicines. 

The Team: UMR1253 iBrain, Team 2, is a highly dynamic and multi-disciplinary team composed by researchers and clinicians. Our close proximity to the Hospital of Tours enable us to develop translational projects in the field of ALS, autism and glioblastoma.